oral aminophylline dosage
15 mg/kg/day PO given in 2 divided doses up to 1,200 mg/day for 10 days for 1 to 2 viable parenchymal lesions, up to 1,200 mg/day in combination with praziquantel for more than 2 viable parenchymal lesions, and up to 800 mg/day for 1 to 2 weeks for degenerating intraparenchymal neurocysticercosis. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes. ciprofloxacin (mixture) oral and aminophylline oral. Store aminophylline in its original container, tightly closed and away from sun, heat and moisture. Do not store in the bathroom. Aminophylline is a xanthine derivative used as a central nervous system stimulant in the management of Apnoea of Prematurity. In any case, the intravenous administration of the medicine should be performed with the patient in supine and with controlled slow (15-20 minutes). We therefore attempted to determine: 1) whether continuous aminophylline infusion is actually beneficial, 2) whether the TDM (treatment drug monitoring) system can be used to establish a protocol for prescribed dosing after an early switch from i.v. $38.84. Oral tablets (extended release) have 90-100% bioavailability Salt factor for aminophylline ~ 0.8 225mg aminophylline~180mg theophylline Theophylline Oral syrup (unlicensed Special) 50mg/5ml Current total daily dose of theophylline, Result mg/L Symptoms & Dose Tolerance Action Dosage forms: Oral, intravenous infusion. Concomitant use of theophylline and ciprofloxacin has decreased theophylline clearance and increased plasma levels and symptoms of toxicity. Ethylenediamine is used to improve how well theophylline dissolves in water. Cat: 6.6 mg/kg orally every 12 hours. ciprofloxacin oral will increase the level or effect of aminophylline iv by affecting hepatic enzyme CYP1A2 metabolism. Take aminophylline exactly as directed. The dose of this medicine will be different for different patients. The IV contains 2g Aminophilline in 250 mL ciprofloxacin (mixture) oral will increase the level or effect of aminophylline oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dose conversion. 11. Dosing Information Aminophylline for Dogs and Cats Hepatic Dose : Use with caution as aminophylline clearance is reduced. Aminophylline was then given orally at a 400 mg loading dose followed by 300 mg doses every six hours. Some side effects may need immediate medical help. Aminophylline is also available as an injection; this is usually given in hospital. Aminophylline is a drug combination of theophylline and ethylenediamine in a ratio of 2 to 1. Read "Individualized aminophylline therapy in patients with obstructive airway disease: Oral dosage prediction from an intravenous test dose, European Journal of Clinical Pharmacology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Always try to take your medicine in time. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Maintenance dose: Aminophylline generic is a bronchodilator, prescribed for symptoms of asthma, bronchitis and emphysema. It is used as a bronchodilator and also as an antidote to dipyridamole toxicity. Aminophylline dosage in acute severe asthma. Terbutaline is an oral drug used to treat asthma, and bronchospasm caused by bronchitis or emphysema. It is … Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic … The dose of aminophylline may be administered on the principle that 0.6 mg aminophylline/kg lean body weight will increase the serum theophylline concentration by 1 microgram/mL. Phyllocontin, Uniphyllin, Slo-Phyllin, Nuelin, Theo-Dur. multiply the hourly dose by 24. Inactive Ingredients: Ethylenediamine, raspberry flavor, … The following information includes only the average doses of this medicine. As aminophylline hydrate: 0.7 mg/kg/hour, decreasing to 0.5 mg/kg/hour after 12 hours. Dosage: Aminophylline is available in tablets, oral liquid, injection and suppository form. This medicine is used to treat the symptoms of asthma, bronchitis, and emphysema. Aminophylline dosage. Aminophylline may cause any of the following side effects: headache, dizziness, nausea, vomiting, diarrhoea, stomach pain or irritation, difficulty in passing urine, rash, itchy skin, irritability, and difficulty sleeping. After 24 hours of drug treatment, ambulatory ECG recording was performed for 24 hours. a stomach ulcer;seizures;heart problems;fluid in your lungs;a thyroid disorder;cirrhosis, hepatitis, or other liver problems;kidney disease; ora serious infection called sepsis. Throughout four hours of testing, mean theophylline concentrations in the blood were higher with oral administration after fasting than Aminophylline Injection is administered by slow intravenous injection or diluted and administered by intravenous infusion. Aminophylline Oral Liquid is available as a solution intended for oral administration, containing 105 mg of anhydrous Aminophylline per 5 mL (equivalent to 90 mg of anhydrous theophylline per 5 mL). Aminophylline comes as a tablet and syrup to take by mouth and a suppository to insert rectally. The recommended dose is 6 mg/kg given intravenously over 20 to 30 minutes, followed by a maintenance dose of 0.5 mg/kg/h. This gives the equivalent oral dose to be 420mg twice a day. Aminophylline may cause any of the following side effects: headache, dizziness, nausea, vomiting, diarrhoea, stomach pain or irritation, difficulty in passing urine, rash, itchy skin, irritability, and difficulty sleeping. Dog: 10 mg/kg orally every 8 hours. The total daily dose should be divided and given PO every 8 hours. 43. 2. Aminophylline Dosage. Theophylline disposition after an intravenous test dose of aminophylline was determined in 83 subjects: 7 patients with and 58 without congestive heart failure (CHF), and 18 healthy controls. -Acute symptoms: Loading dose: Oral, I.V. Loading doses should be administered over 30 minutes at a rate not to exceed 21 mg/hr and should be calculated using ideal body weight. On a multiple-dose schedule of oral aminophylline (200 to 300 mg. every 6 hours) “trough” levels of serum theophylline in 83 patients ranged from 2.9 to 32.6 µg per milliliter. When initiating continuous oral aminophylline therapy, dosage guidelines, based on the mean ATC calculated for each group, were predicted, and trough theophylline serum levels of 10mug/ml were obtained. Administration may be oral, intramuscular, intravenous, or rectal. $38.53. When initiating continuous oral aminophylline therapy, dosage guidelines, based on the mean ATC calculated for each group, were predicted, and trough theophylline serum levels of 10μg/ml were obtained. Phyllocontin (aminophylline) tablets contain aminophylline hydrate. Maintenance dose: 62.5 to 500 micrograms daily (higher doses may be divided). In order to calculate the equivalent theophylline dose, multiply this total aminophylline dose by 0.8, which is the salt correction factor (1). Aminophylline has a narrow therapeutic index, therefore cautious dosage determination is essential. Decrease the dose in patients with liver disease. Yes Throughout four hours of testing, mean theophylline concentrations in the blood were higher with oral administration after fasting than AMINOPHYLLINE 50 MG/ML ORAL SUSPENSIONS. concentration should be obtained. Salt factor for aminophylline ~ 0.8 225mg aminophylline ~180mg theophylline Monitoring: Therapeutic drug level monitoring of theophylline should be undertaken when patients are switched from KItETICSOFTHEOPHYLLINEANDAMINOPHYLLINE 271 8 2.8 E >1 0S3 1 2 3 4 5 6 7 8 9 10 Time after dosing (h) Figure 1 Theserumconcentrations (meanands.e. Adult dosage (ages 18–59 years) The usual starting dose is 300–400 mg per day. Theophylline was not shown to be teratogenic in CD-1 mice at oral doses up to 400 mg/kg, approximately 2.0 times the human dose on a mg/m 2 basis or in CD-1 rats at oral doses up to 260 mg/kg, approximately 3.0 times the recommended human dose on a mg/m 2 basis. Aminophylline is a drug combination of theophylline and ethylenediamine in a ratio of 2 to 1. Add the required dose to 100ml compatible fluid (sodium chloride 0.9% or glucose 5%) and administer over 30 minutes. Aminophylline is a 2:1 mixture of theophylline and ethylenediamine. Pregnancy Category C . Do not exceed 400 mg/day IV or PO in patients > 16 years, or 16 mg/kg/day up to 400 mg/day PO in patients 16 years. After 3 days, your dose may be increased to 400–600 mg per day if you don’t have any side effects. Uniphyllin Continus® (theophylline) is licensed for the same indications as above. Use ideal (lean) body weight to calculate dose. An average 96% (range 75 to 105%) of an uncoated … Maximum initial dose = 0.2 mg/kg/day IV (theophylline) in patients > 1 year. DO NOT GIVE loading dose if the patient takes oral theophylline or aminophylline Maintenance Infusion: 1 month – 11 years: 1mg/kg/hour 12 – 17 years: 0.5mg/kg/hour Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Knowledge acquired of the kinetic disposition and effects of theophylline over the past 8 years has increased the clinical utility of the drug in the treatment of cardiorespiratory disorders. ; Child: >3 yr: As modified-release hydrate: 12 mg/kg daily increased to 24 mg/kg daily in 2 divided doses after 1 wk. A simplified approach for this conversit)n is to multiply the mg/. Aminophylline | C16H24N10O4 | CID 9433 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ... Follow your doctor's orders or the directions on the label. 11 minor drug interactions. Aminophylline Oral vs Rectal Administration James P. Lillehei, MD The widespread preference for rectal rather than oral administration of aminophylline was questioned and com-parisons were made in 13 adults. Loading dose: 750micrograms to 1.5mg orally in single or divided doses (6 hours apart) over 24 hours. Adult: As hydrate: Initially, 225-450 mg bid, increased if necessary. In 27 cases of acute severe asthma, a loading dose of 5 mg/kg of aminophylline (omitted if already receiving oral theophylline) followed by a continuous infusion of 1 mg/kg per hour gave satisfactory theophylline levels at 4 h and 24 h. Theophylline clearance rates varied widely, vomiting was common …. If a patient is admitted on oral aminophylline or theophylline take a level 6 hours after it was last taken and omit the loading dose. Oral bronchodilators are available as capsules, tablets and oral liquids. AMINOPHYLLINE 100 MG/ML ORAL SUSPENSIONS. It’s more difficult if the patient has to be switched from aminophylline to theophylline, as the doses are different. Converting Intravenous Aminophylline to Oral Aminophylline or Theophylline. Can aminophylline be given IV push? Aminophylline Injection B.P. 250mg/10ml is for slow intravenous administration. The solution may be injected very slowly, or it may be infused in a small volume of either 5% dextrose or 0.9% sodium chloride injection. Aminophylline should not be administered concomitantly with other xanthine drugs. Theophylline dose is 80% of aminophylline dose. IV aminophylline dosage adjustments based on age and underlining medical conditions have been documented, 15 but there is no real recommendation for an oral aminophylline dosage in the current literature. Avoid use when taking any oral drug that is dependent on threshold concentrations for efficacy. Dosages . If the IV aminophylline dose is 35mg/hr and the dosing interval for oral aminophylline is every 12 hours, i.e. Intravenous or Oral maintenance dosage (aminophylline or theophylline) Term Neonates and Infants.
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